Author

S. Munir Alam

Duke UniversityORCID 0000-0002-5618-7674Unclaimed ORCID profile · follow to get notified of new preprints

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S. Munir Alam1 paper · Duke University

Biology Disciplines

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Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:cryo-EM· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1

Frequent Co-Authors

Advaiti Pai KaneiD· 1 shared Hung Nguyen DoiD· 1 shared Kara M. AnastiiD· 1 shared Kenneth D. CroniniD· 1 shared Michael G. RethiD· 1 shared Mingfei ZhaoiD· 1 shared Sandrasegaram GnanakaraniD· 1 shared Yaneth M. OrtiziD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 13 mutual co-author links

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1 shared paperImmunology

Advaiti Pai KaneORCID

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2 papers

Recent·Most cited

BiophysicsCommunications BiologyPeer-reviewedFeb 13, 2025

Dynamics and Activation of Membrane-Bound B Cell Receptor Assembly

Hung Nguyen Do, Mingfei Zhao, S. Munir Alam, Sandrasegaram Gnanakaran

This study uses molecular dynamics simulations to identify two dynamical events in B-cell receptor activation upon antigen binding.

2 citations

𝕏 PostBluesky

ImmunologyProceedings of the National Academy of SciencesPeer-reviewedJul 23, 2024

Class-specific sensing of HIV-1 antigens by the B cell antigen receptor depends on the CH1 domain

Yaneth M. Ortiz, Kara M. Anasti, Advaiti Pai Kane…·Michael G. Reth

This study shows that IgM and IgG1 BCRs differ in antigen sensing based on valency, with IgM preferring monovalent and IgG1 preferring polyvalent antigens, and identifies the CH1 domain as responsible for this difference.

3 citations

humanproteomics

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