Kenneth D. Cronin

This study reports cryo-EM structures of full-length BCRs, revealing their dynamic conformation and antigen binding-induced signaling mechanisms.

This study shows that a multi-dose immunization with germline-targeting SOSIP vaccines induces precursor broadly neutralizing antibodies in infant macaques, similar to adult responses.

This study shows that IgM and IgG1 BCRs differ in antigen sensing based on valency, with IgM preferring monovalent and IgG1 preferring polyvalent antigens, and identifies the CH1 domain as responsible for this difference.