Zhe J. Liu

The paper shows that actin polymerization in dendritic shafts positions endocytic compartments at stimulated spine bases, enhancing glutamate receptor turnover and spine enlargement.

This study uses single-particle tracking to show that ARC/ARG3.1 protein shuttles between cytoplasmic clusters and the nucleus in response to synaptic activation.

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

This paper introduces a series of spontaneously blinking dyes with adjustable duty cycles for improved single-molecule localization microscopy in cells and dense structures.

The paper presents a spatial omics framework combining protein and RNA imaging with machine learning to classify brain cell types and discover structural features at tissue scale.

This paper introduces cycleHCR technology for high-resolution spatial transcriptomics and protein imaging in thick tissues, demonstrating its application in mouse embryos and brain slices.

The paper investigates how 3D genome organization, specifically through Cohesin, influences gene co-expression in single cells and reveals its role in maintaining long-range chromatin interactions.

The paper investigates how actin polymerization in dendritic shafts regulates the trafficking of AMPA receptor-containing vesicles during long-term potentiation.

The paper uses correlative single molecule lattice light sheet imaging to study nucleosome dynamics and chromatin environment interactions in live cells, revealing differential diffusion and packing with increasing chromatin density.

This study reanalyzes Brd2 depletion effects on chromatin compartments using Micro-C data and cooltools, showing persistent but reduced compartment strength changes.

This study develops optical imaging methods to analyze subcellular localization and dynamics of voltage-gated sodium channels in neurons, revealing developmental regulation and a novel trafficking pathway.

This study uses super-resolution imaging to reveal the 3D structure and organizing mechanism of accessible chromatin domains.

This study investigates transcriptional bursting kinetics in mESCs using scRNA-seq and identifies regulatory factors and pathways influencing gene expression noise.

The paper introduces a new genetically encoded voltage indicator, Voltron, which improves brightness and photostability for extended in vivo voltage imaging in mice, zebrafish, and fruit flies.

The paper shows that astrocytes detoxify fatty acids from hyperactive neurons through mitochondrial oxidation, protecting neurons from toxicity.

This study uses live-cell imaging to show MeCP2 has unique diffusion and chromatin binding kinetics in neurons, distinct from transcription factors and histones.