Lars Ingo Ole Leichert

This paper identifies RcrB as a detoxification system in uropathogenic Escherichia coli that protects against reactive chlorine species like HOCl by reducing extracellular HOCl and maintaining redox homeostasis.

This study shows auranofin forms S-Au-S bonds between cysteine thiols in proteins, independent of thioredoxin reductase, suggesting a new mechanism for its antibacterial activity.

This study identifies the ABC transporters Gsi and Opp as essential for glutathione import into E. coli, with Gsi specifically required for oxidized glutathione uptake.

This paper investigates how auranofin affects Gram-positive and Gram-negative bacteria, finding that Gram-negative bacteria are more resistant due to efflux systems and glutathione levels.