Vinay Kumar Nandicoori

This study identifies SecA1 and TatA as critical for Mycobacterium tuberculosis membrane integrity through multi-omics and functional genetics analyses.

This study identifies PE11 as a factor that promotes Mtb persistence by inhibiting autophagy and lysosomal biogenesis through the FLCN-lactate-TFEB signaling axis, with lactate shown to enhance bacterial clearance.

This study identifies Wag31's role in lipid homeostasis in mycobacteria by showing its tethering activity and interactions with membrane proteins.

This study characterizes the structure and function of PE11 esterase from Mycobacterium tuberculosis, showing its role in virulence and potential as a therapeutic target.

The paper identifies a Q135K mutation in uvrA of Mycobacterium tuberculosis that confers survival advantage under oxidative stress and in macrophages, enhancing host adaptability.

This paper identifies a Mycobacterium tuberculosis secreted protein that disrupts host snRNP biogenesis, altering RNA splicing and contributing to pathogenesis.

This study identifies a mitochondrial quality control mechanism that reverses phagosome maturation arrest caused by Mycobacterium tuberculosis through RAB7 recruitment and lysosomal targeting.