James A. Watson

This study shows MeCP2 binds methylated DNA in nucleosomes via linker DNA interactions beyond its canonical methyl binding domain, revealing a new mechanism for chromatin DNA methylation recognition.

This study determines the structure of H3.V-H4.V nucleosomes in Trypanosoma brucei and shows how these variants promote nucleosome plasticity in repressed chromatin.

This study identifies the N-terminal region of DNMT3A as containing multiple chromatin-binding motifs that mediate recruitment through interactions with nucleosomes and ubiquitylated histone H2AK119.