Alpha S. Yap

This study shows PIEZO1 supports apoptotic cell extrusion by maintaining mechanical homeostasis rather than through calcium signaling.

This study identifies a mechanism where invading cells and tissue barriers coordinate to rupture barriers through intercellular adhesions and subcellular contractility, challenging existing models of collective invasion.

The paper introduces a method to analyze nematic order on tissue surfaces of arbitrary geometry, validated in vitro and in vivo, revealing physical insights through 3D reconstruction from 2D image stacks.

This study introduces a new method to measure energy dissipation during cell-cell junction rupture and shows that cortical tension and shape relaxation time determine whether junctions behave ductile or brittle.

This study shows that partial reduction of BECLIN1 in intestinal epithelial cells leads to intestinal defects and increased susceptibility to inflammation, suggesting its importance in maintaining gut health.

This study investigates the role of BECLIN-1 in maintaining gastrointestinal epithelial integrity by regulating endocytic trafficking, F-actin organization, and lysosomal function using organoids from BECLIN-1 knockout mice.

This study shows that an APC truncation mutant increases epithelial tissue tension via RhoA/ROCK, impairing apical cell extrusion and potentially contributing to disease.

This study shows that c-Src activation in endothelial cells causes vascular expansion through focal adhesion signaling and localized matrix degradation, which can be inhibited to prevent abnormal vascular growth.

The paper introduces a transgenic Lifeact-EGFP quail line for live imaging of actin dynamics during avian embryogenesis and demonstrates its utility in studying cellular protrusions and supracellular actin structures.

This study shows Snail induces cell extrusion through RhoA contractile signaling and reduced basal adhesion, independent of EMT.

This paper identifies anillin's role in RhoA contractile signaling by stabilizing active GTP-RhoA and promoting contractility through a non-classical scaffolding mechanism.