Canavanine-based assay for gross chromosomal rearrangements reveals genome instability hotspots and modulating genes in fission yeast
Anissia Ait Saada, Cassandre Ollivier, Alex B. Costa…·Kirill S. Lobachev
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Georgia Institute of TechnologyORCID 0000-0002-5775-1679Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
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Anissia Ait Saada, Cassandre Ollivier, Alex B. Costa…·Kirill S. Lobachev
Alex B. Costa, Anissia Ait Saada, Thy Pham…·Kirill S. Lobachev
The paper identifies a pathway involving Smc5/6 and Rtt107 that promotes palindrome-mediated genome instability through cruciform formation and cleavage.
Tony M. Mertz, Elizabeth Rice-Reynolds, Ly Thi Huong Nguyen…·Steven A. Roberts
This paper identifies genetic modifiers of APOBEC-induced mutagenesis in yeast and human tumors, revealing factors that influence mutation patterns and DNA repair mechanisms.
Brooke Rothschild-Mancinelli, Claudia Álvarez-Carreño, Wenying Guo…·Loren Dean Williams
This paper demonstrates the directed evolution of the Saccharomyces cerevisiae mitochondrial translation system as an orthogonal system to the cytosolic TS, revealing functional dependencies and enabling translation engineering.
Anissia Ait Saada, Alex B. Costa, Kirill S. Lobachev
This study identifies a dominant any1 mutation that confers strong canavanine resistance in fission yeast, enabling its use as a genetic selection marker.