Jinghua Ge

This study shows that two MYO1E mutations, A92E and G562R, impair Myo1e localization and function, contributing to steroid-resistant nephrotic syndrome.

This study investigates how the E525K mutation in cardiac myosin affects its structure and function by analyzing conformational changes using cryo-EM and MD simulations.

The paper uses cryo-EM to determine the structures of myosin bound to two cardiomyopathy drugs, revealing how they modulate myosin conformation to control cardiac contractility.

QuickStainer improves preservation of labile macromolecules by rapidly staining samples with minimal incubation time on the carbon grid.

This paper investigates how the E525K mutation in beta-cardiac myosin affects actin activation, power stroke, and phosphate release, revealing structural and kinetic changes linked to dilated cardiomyopathy.