Author
University of OtagoORCID 0000-0002-5850-0919Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Suzanna H. Harrison, Rowan C. Walters, Chen‐Yi Cheung…·James N. Blaza
This study uses remission spectroscopy to show bedaquiline inhibits ATP synthase in mycobacteria, redirecting electron flux through cytochrome bd oxidase and increasing O2 consumption, without uncoupling.
Justin M. Di Trani, Jiacheng Yu, Gautier M. Courbon…·John L. Rubinstein
The paper uses cryo-EM to show that malate-quinone oxidoreductase associates with the CIII2CIV2 supercomplex in mycobacteria, linking Krebs cycle and respiration.
Adam J. Fountain, Natalie J.E. Waller, Chen‐Yi Cheung…·Lalita Ramakrishnan
XinYue Wang, William J Jowsey, Chen‐Yi Cheung…·Matthew B. McNeil
The paper identifies vulnerabilities in isoniazid-resistant Mycobacterium tuberculosis strains by analyzing metabolic and transcriptional changes in katG mutants.
Matthew B. McNeil, Laura M. Keighley, Josephine R. Cook…·Gregory Murray Cook
This study uses CRISPR interference to assess the vulnerability and lethality of 96 target genes in Mycobacterium tuberculosis, identifying bactericidal and bacteriostatic effects across different cellular pathways.