Jean‐Luc Battini

This study identifies XPR1 as a regulator of GSDMD-independent IL-1β secretion in human monocytic cells, linking it to phosphate export and revealing a novel pathway for cytokine release.

This study determines the cryo-EM structure of XPR1, identifies Pi-binding sites, and shows how PP-IPs regulate its activity through conformational changes.

The study shows that amino acid balance, not energy metabolism, promotes HIV-1 replication in primary CD4 T cells under near-physiological conditions.