Dominique Engel

This study shows that Ccp1 depletion in hippocampal parvalbumin interneurons leads to hyperglutamylation, impaired axonal transport, and reduced perisomatic inhibition of pyramidal cells in the CA2 region.

The paper shows that extrasynaptic NMDARs, activated by glycine and glutamate spillover, drive bursting in nigral dopamine neurons, while synaptic NMDARs use D-serine.

The paper identifies an unconventional conductance essential for pacemaking in nigral dopamine neurons using pharmacological evidence and electrophysiological analysis.