S. Munir Alam

This study reports cryo-EM structures of full-length BCRs, revealing their dynamic conformation and antigen binding-induced signaling mechanisms.

The paper shows that B cell receptor signaling sets limits on the selection of functional mutations in antibodies, with mid-affinity antigens showing optimal neutralization.

This study identifies binding dynamics as a key factor in enhancing germinal center responses to HIV immunogens, improving the efficiency of somatic hypermutation and bnAb precursor activation.

This study shows that a multi-dose immunization with germline-targeting SOSIP vaccines induces precursor broadly neutralizing antibodies in infant macaques, similar to adult responses.

This study shows non-neutralizing SARS-CoV-2 antibodies protect mice from severe disease via Fc-mediated effector functions, reducing viral load and lung damage.

The paper shows that boosting RV144 vaccine recipients with ALVAC-HIV and AIDSVAX B/E increases C1C2-specific antibody-dependent cellular cytotoxicity breadth and potency.