Wolfgang Sippl

This study identifies SNHG29 and IGF2BP1 as a lineage-specific oncogenic circuit in AMKL, showing their dependency and therapeutic vulnerability.

This study develops MA191, a PROTAC degrader of FLT3-ITD, which overcomes resistance in AML cells by rapidly degrading the mutant protein and shows efficacy in vivo.

The paper uses machine learning to identify novel HDAC6/AKT2 inhibitors for myeloid cancer treatment, finding compounds with potent anticancer activity.

This study identifies SmHDAC8 as involved in cytoskeleton organization through its interaction with SmRho1 isoforms in Schistosoma mansoni, showing acetylation of SmRho1 and disruption of actin cytoskeleton upon SmHDAC8 inhibition.

This study shows that inhibiting SmLSD1 with MC3935 causes transcriptional changes and structural damage in Schistosoma mansoni, leading to parasite death.