Daniel L. Minor

This study shows that RcSxph from American bullfrogs can counteract saxitoxin poisoning in mice by binding the toxin, validating its role as a toxin sponge.

This study identifies saxiphilin as a toxin sponge that binds multiple C13-modified saxitoxin congeners, revealing structural adaptability and conformational plasticity in toxin-protein interactions.

This paper identifies a lipid plug in K2P6.1 channels that regulates their activity by occupying the central cavity and preventing ion permeation.

This paper identifies the structural basis for saxitoxin congener binding and neutralization by saxiphilins, showing how these proteins sequester toxins and reverse sodium channel blockage.

This paper presents cryo-EM structures of human K2P13.1 (THIK-1) revealing a novel hydrophilic pore restriction and lipid cofactor site, with implications for modulator development.

This paper develops a chemogenetic method to irreversibly activate K2P channels, enabling studies of their function and potential therapeutic applications.