Tsutomu Kume

This paper introduces SC-LSS, an automated tool for volumetric segmentation of Schlemms Canal in OCT images, showing high agreement with manual segmentation and detecting changes in SC size under different intraocular pressure conditions.

This study identifies FOXC1 and FOXC2 as essential regulators of intestinal regeneration after ischemia-reperfusion injury by promoting paracrine signaling from endothelial cells.

This study investigates the roles of Foxc1 and Foxc2 in limb development, showing they are critical for chondrocyte hypertrophy and mineralization in the primary ossification center.

The paper investigates the role of FOXC2 in neural crest- and endothelial-derived cells in the trabecular meshwork and Schlemms Canal, showing its importance in development and maintenance of the aqueous humor outflow pathway in glaucoma.

The paper shows that FOXC1 affects ciliation and cilia-dependent signaling, contributing to pleiotropic phenotypes in Axenfeld-Rieger Syndrome.