Warren Ladiges

This paper uses serum protein profiling to identify aging trajectories and strain-specific resilience in mice, revealing pathway-level changes and heterogeneity between strains.

The paper introduces a Composite Frailty Index (CFI) in house crickets to quantify functional aging and identify gerotherapeutic drugs.

This study tests intermittent dosing of rapamycin, acarbose, and phenylbutyrate in house crickets, finding lifespan extension and improved locomotion and cognition in some treatments.

This study shows that house crickets exhibit age-related cognitive decline, including sensory and learning impairments, similar to humans, making them a useful model for studying aging mechanisms.

This study shows that GHK-Cu improves cognitive function in aged mice through different molecular mechanisms depending on delivery route and duration.

This study develops an organotypic brain slice culture model from geriatric mice, showing viability and response to stressors, suggesting its potential for aging and neurodegenerative disease research.

This study analyzes age- and sex-dependent morphological changes in house crickets, highlighting structural adaptations and environmental factors affecting aging research.

This study compares age-related decline and behavioral validity in C57BL/6 and CB6F1 mice, finding strain-specific differences in behavior, physiology, and organ pathology.

This study shows intranasal GHK-Cu treatment reduces cognitive impairment, amyloid plaques, and inflammation in 5xFAD mice, suggesting potential as an AD therapy.

This study shows that intranasal GHK-Cu improves cognitive performance and reduces neuroinflammatory and axonal damage markers in aged mice.

This study shows a drug cocktail improves cognitive function in aged mice by modulating aging pathways through transcriptomic and molecular analyses.

A cocktail of rapamycin, acarbose, and phenylbutyrate slowed aging in mice by improving health metrics and reducing age-related lesions.