Author

Richard S. Lehner

University of AlbertaORCID 0000-0002-6008-1805Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Russell WattsiD· 2 shared Aducio ThieseniD· 1 shared Ariel D. QuirogaiD· 1 shared Cyrus A. Nikain· 1 shared Donna Faye VineiD· 1 shared Edward A A FisheriD· 1 shared Haizhen WangiD· 1 shared Ira J. GoldbergiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPhysiology

Russell WattsORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintMay 12, 2026

Endoplasmic Reticulum Associated Lipolysis Regulates Hepatic Fat Synthesis and Turnover

Jihong Lian, Russell Watts, Randal Nelson…·Richard S. Lehner

This study identifies AADAC as a regulator of hepatic lipid metabolism, showing its role in suppressing lipid synthesis and preventing MASLD under overnutrition.

DOI 10.64898/2026.05.08.723884

mouseexperimental assay

𝕏 PostBluesky

BiochemistryMolecular MetabolismPeer-reviewedOct 18, 2024

FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion in vitro and in mouse liver

Haizhen Wang, Cyrus A. Nikain, Konstantinos I. Fortounas…·Edward A A Fisher

This study shows FITM2 deficiency reduces VLDL triglyceride secretion and causes ER stress and lipid accumulation in liver cells and mice.

19 citationstop 3%

mousebulk RNA-seq

𝕏 PostBluesky