Author
Amgen (United States)ORCID 0000-0002-6009-9431Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Miguel A. Alcantar, Alexandra M. Paulk, Shoeib Moradi…·Chang C. Liu
This paper evolves computationally designed protein binders using in vivo hypermutation and maps their sequence-affinity landscapes to understand affinity improvements and mutation interactions.
Natalia E. Ketaren, Peter C. Fridy, Vladimir N. Malashkevich…·Michael P. Rout
This study identifies mechanisms enabling nanobodies to bind antigens with high affinity and stability, revealing a conserved region critical for their function and suggesting strategies for their optimization.
You Yu, Shibai Li, Zheng Ser…·Xiaolan Zhao
The paper presents an integrative structural analysis of the Smc5/6 complex in budding yeast, revealing unique structural features and functional interactions among its subunits.