En-Zhi Shen

The paper catalogs endogenously tagged proteins in C. elegans, identifies gaps in coverage, and provides a database with tools for designing knock-in experiments.

This study reveals structural and functional features of mammalian PIWI-piRNA-target complexes that enable efficient and broad target silencing.

This study identifies GLH proteins' role in controlling Argonaute pathway specificity and promoting transgenerational silencing in C. elegans by binding to target mRNAs and amplifying small RNAs.

The paper identifies piRNA binding sites in C. elegans germline mRNAs and shows piRNA targeting follows microRNA-like rules, with binding energy more important than piRNA abundance.