Author
University of BristolORCID 0000-0002-6101-6300Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Laura O’Regan, Sarah Bristow, Zuriñe Antón…·Mark P. Dodding
The paper identifies a phosphorylation-dependent gate on kinesin-1 activity mediated by KLC2 CTD, revealing a kinase-kinase code that regulates lysosome transport through adaptor binding and membrane cues.
Emily L. Richardson, Axel Knebel, Kees R. Straatman…·Andrew M. Fry
This study identifies NEK7-mediated phosphorylation of cortactin as a mechanism by which EML4-ALK V3 enhances cell migration through actin cytoskeleton remodeling.
Shivam Shukla, Jessica A. Cross, Monika Kish…·Mark P. Dodding
This study shows that cargo-sensitive TPR switch in kinesin-1 controls its conformational dynamics by dislocating the TPR shoulder, promoting motor domain activation and microtubule binding.
Laura O’Regan, Giancarlo Barone, Rozita Adib…·Andrew M. Fry
The paper shows EML4-ALK V3 promotes cell migration via NEK9 and NEK7 kinases, leading to worse outcomes in lung cancer.