Shailendra Asthana

This study identifies two novel glycolysis inhibitors that block fungal morphogenesis in C. albicans by targeting pyruvate kinase, enhancing antifungal susceptibility and reducing virulence.

This paper identifies BMM_1567, a peptide that enhances aminoglycoside activity against multidrug-resistant Gram-negative bacteria by inhibiting resistance enzymes.

This paper identifies a monoclonal antibody from hybrid immunity that broadly neutralizes multiple Omicron variants by targeting conserved epitopes on the spike protein.

This study identifies BPA-induced ubiquitinome changes in trophoblast cells, showing PPAR-alpha hyper-ubiquitination disrupts migration and may contribute to placental dysfunction.

This study identifies AGPAT1 as a novel receptor for Chikungunya virus on human cells, showing its role in virus binding, uptake, and replication.

This study identifies indole-3 acetic acid (I3A) as an NLRP3 inflammasome inhibitor that mitigates MASLD hallmarks in vitro and in diet-induced mouse models.

The paper shows that SARS-CoV-2 spike antibodies can enhance DENV2 infection in vitro and in vivo, suggesting potential for increased dengue severity in COVID-19 survivors.

This study identifies a cholesterol-binding motif in the VapC12 toxin of M. tuberculosis and shows that cholesterol activates the toxin, reducing bacterial growth and antibiotic susceptibility.

This study shows that the direct sulfhydrylation pathway in Mycobacterium tuberculosis is essential for growth at low pH and modulates BDQ sensitivity.

The paper uses molecular dynamics simulations to study conformational changes in a nicotinic receptor site induced by agonists, identifying key steps in the low-to-high affinity transition.

This study identifies a SNP in the MMP7 promoter that increases hypertension risk by enhancing CREB binding and MMP7 expression under stress conditions.