Johanna Ivaska

This study identifies two distinct mechanisms by which pancreatic cancer cells extravasate: protrusion-driven invasion and endothelial retraction, with implications for anti-metastatic strategies.

The paper identifies a signaling axis involving SorLA, integrin, and HER2/HER3 that regulates apicobasal polarity in mucinous colorectal adenocarcinoma and shows its therapeutic relevance.

This study shows that TNS1 phase separation regulates adhesion dynamics by controlling the availability of inactive adhesion proteins through phosphorylation-dependent condensate formation.

The paper shows that fibrillar adhesions control nuclear mechanical response timescales through vimentin cytoskeleton anchoring via plectin 1f.

The paper shows that tissue mechanics control epithelial multilayering by regulating cell differentiation and movement strategies in the developing mouse epidermis.

This study shows SHANK3 regulates endothelial cell motility and tissue mechanics, affecting vascular development in zebrafish and mice.

This study shows that restoring mechanophenotype or targeting YAP/TAZ can reverse malignant properties of vocal fold cancer by reducing nuclear YAP and β-catenin levels.

This study shows that leupaxin inhibits durotaxis and mechanosensitivity in metastatic breast cancer cells by disrupting paxillin-FAK signaling.

This study uses fast label-free live imaging and deep learning to analyze cancer cell arrest on endothelial monolayers, finding CD44-HA interactions and flow dynamics are key factors.

The paper identifies CCT8 as a MYO10 interactor critical for filopodia functions through proteomics and functional studies in cancer cells.

This study uses dynamic micropatterning to analyze B cell receptor signaling and immune synapse formation, revealing distinct spatial distributions of activated proteins and actin-based protrusion repurposing.

The paper identifies EPLINα's role in integrin recycling via Rab21 endosomes, enhancing breast cancer cell migration and linking EPLIN isoform ratios to mesenchymal phenotypes.

This study shows that macrophages control collagen network topography via Tcf4-Collagen3 pathway, influencing immune cell infiltration in tumors.

This study identifies TLNRD1 as a CCM complex component that regulates endothelial barrier integrity by modulating actin bundling.

The paper investigates the three-dimensional architecture of unique focal adhesions in human pluripotent stem cells and identifies structural features linked to pluripotency maintenance.

This study shows vimentin supports mammary gland development and stem cell function in mice and breast cancer cells by affecting ductal outgrowth, cell proportions, and tumor sphere formation.

ProLIF quantitatively measures integrin-protein interactions in proteoliposomes using flow cytometry, enabling analysis of membrane effects on protein recruitment.