Amit Singh

This paper develops a genetically encoded biosensor, rmgCarvi, to monitor cAMP dynamics in Mycobacterium tuberculosis at single-cell resolution, revealing how cAMP levels coordinate growth and resuscitation in response to nutrient availability and host environments.

This study identifies SIRT2 as a regulator of stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signaling, showing protective effects in mice.

This paper investigates the molecular mechanism of aminooxyacetic acid (AOAA) inhibition of MtbCBS, a key bacterial enzyme, using cryo-EM and computational methods, revealing critical residues and structural factors for irreversible inhibition.

This study shows that SIRT1 and SIRT3 regulate mitochondrial function and pH balance in macrophages during Salmonella infection, affecting bacterial gene expression.

This study shows that altering macrophage metabolism can reduce drug tolerance in Mycobacterium tuberculosis by affecting bacterial redox states.

This study identifies a mitochondrial quality control mechanism that reverses phagosome maturation arrest caused by Mycobacterium tuberculosis through RAB7 recruitment and lysosomal targeting.