Pragya Goel

This study compares striatal pathology in SCA1 and HD mice, finding shared and distinct molecular and functional deficits in Medium Spiny Neurons.

This study uses botulinum neurotoxin to isolate neurotransmission from tonic and phasic neurons in Drosophila, revealing heterosynaptic plasticity rules.

This study shows that excess glutamate release selectively regulates GluR subtypes through competition and Ca2+ signaling in Drosophila.

The paper identifies distinct target-specific mechanisms that stabilize synaptic strength at pre- and post-synaptic compartments in Drosophila neuromuscular junctions.

The paper investigates how synaptic strength is maintained in Drosophila larvae arrested in development, finding that presynaptic homeostatic depression compensates for excessive synaptic growth.

This study identifies the sleep gene insomniac as essential for retrograde homeostatic signaling by ubiquitinating targets at postsynaptic densities in Drosophila.

The paper screens Drosophila genes affecting synaptic growth and identifies three mechanisms that stabilize synaptic strength despite growth changes.

The paper identifies a molecular mechanism for presynaptic plasticity involving rapid remodeling of active zone modules, which sustains neurotransmitter release potentiation over time.

The paper uses CRISPR to tag Ca2+ channels in Drosophila and shows they are differentially regulated during presynaptic homeostatic potentiation and depression.