Elli Marinopoulou

The paper shows that oscillatory co-expression of HES1 and HES5 allows hybrid states in a bistable transcription factor motif by enabling phase-locking and entrainment.

This study shows NGN3 protein oscillations control timing of human pancreatic endocrine differentiation, not fate, through fold-change detection via an incoherent feedforward motif.

The paper shows that cell coupling compensates for altered Her6 dynamics in zebrafish neural progenitors, maintaining phenotypic robustness despite single-cell expression changes.

The paper identifies oscillatory genes in glioblastoma, including SOX2, which oscillates in quiescent glioblastoma stem cells, suggesting new regulatory roles in quiescence.

OscoNet improves upon Oscope by providing a statistical criterion for selecting oscillatory genes and a more accurate pseudo-time estimation method.