Oliver Cottrell

The paper introduces a framework for engineering tunable oscillatory protein expression using Tet-On and dTAG degron systems, demonstrating synchronous oscillations with the COD system.

This study shows that HES1 protein oscillations are necessary for ER+ breast cancer cells to re-enter the cell cycle, and disrupting these oscillations prevents reactivation of dormant cells.

The paper identifies oscillatory genes in glioblastoma, including SOX2, which oscillates in quiescent glioblastoma stem cells, suggesting new regulatory roles in quiescence.