Andrew Rowntree

The paper introduces a framework for engineering tunable oscillatory protein expression using Tet-On and dTAG degron systems, demonstrating synchronous oscillations with the COD system.

This study shows that HES1 protein oscillations are necessary for ER+ breast cancer cells to re-enter the cell cycle, and disrupting these oscillations prevents reactivation of dormant cells.

This study shows NGN3 protein oscillations control timing of human pancreatic endocrine differentiation, not fate, through fold-change detection via an incoherent feedforward motif.

The paper identifies oscillatory genes in glioblastoma, including SOX2, which oscillates in quiescent glioblastoma stem cells, suggesting new regulatory roles in quiescence.