Peter John Espenshade

This study shows that SREBP pathway inhibition slows PDAC tumor growth by disrupting lipid homeostasis, suggesting SCAP as a therapeutic target.

The paper identifies geranylgeranyl diphosphate as essential for pancreatic cancer growth through in vivo CRISPR screening and shows that targeting its synthesis reduces tumor burden.

This study identifies new substrates of the prolyl hydroxylase Ofd1 in fission yeast using quantitative proteomics, revealing expanded biological functions beyond its known role in ribosome regulation.