Jan Otto Wirth

The paper shows that clustering of voltage-gated sodium channels affects their biophysics, leading to different pharmacological responses and potential therapeutic implications.

The paper demonstrates that using diffraction minima allows resolving point scatterers at distances as small as 1/80 of the wavelength, improving measurement precision with closer scatterers and higher density.

This study identifies a two-heads-bound state in KIF1A that enhances processivity and is critical for neuronal transport, contrasting with Kinesin-1's one-head-bound state.

This study uses MINFLUX to track dynein movement in live neurons, revealing 8 nm steps and rapid direction reversals, suggesting a single ATP-dependent stepping mechanism.

This study uses MINFLUX to analyze kinesin-1 dynamics in neurites, identifying ATP-binding states and microtubule switching behavior.