Stefan W. Hell

This study compares the accuracy of two single-molecule localization methods in microscopy, finding that MINFLUX significantly outperforms camera-based methods.

This paper introduces a 3D MINSTED nanoscopy method for tracking single proteins in live cells with sub-nanometer precision, demonstrating its application to kinesin-1 movement along microtubules.

This paper demonstrates the ability to track nanometric movements of fluorophores using MINFLUX microscopy, showing sub-10 nm distance changes can be detected within milliseconds.

This paper introduces caging-group-free photoactivatable fluorophores with far-red emission for improved super-resolution microscopy.

The paper demonstrates that using diffraction minima allows resolving point scatterers at distances as small as 1/80 of the wavelength, improving measurement precision with closer scatterers and higher density.

This study demonstrates MINFLUX fluorescence nanoscopy's ability to achieve sub-10 nm resolution for protein localization in thick mouse brain tissue sections.

This study uses MINFLUX to track dynein movement in live neurons, revealing 8 nm steps and rapid direction reversals, suggesting a single ATP-dependent stepping mechanism.

This study uses MINFLUX to analyze kinesin-1 dynamics in neurites, identifying ATP-binding states and microtubule switching behavior.

This paper introduces a 4Pi MINFLUX technique that achieves high spatio-temporal localization precision for single fluorophores, revealing nanoscale diffusion heterogeneities in solutions.

The paper shows that a small population of synaptic vesicles contain different neurotransmitter transporters, enabling corelease of various neurotransmitter combinations.

The paper identifies a molecular mechanism for presynaptic plasticity involving rapid remodeling of active zone modules, which sustains neurotransmitter release potentiation over time.