Thibault Tubiana

This study identifies a dimerization site in NS5A that enhances HCV replication fitness by promoting self-interaction, which inhibits NS3 and NS5B activity.

This study identifies ZDHHC17-mediated palmitoylation of HEV ORF3 protein as critical for directional secretion in polarized epithelial cells.

This study investigates two flexible regions of the HEV ORF1 replicase using structural modeling and mutagenesis, showing their functional importance in viral replication.

This study shows 4'-fluorouridine inhibits Oropouche virus replication in vitro and in animal models, with no resistant variants observed.

This study identifies ORF2 as a key HEV protein that suppresses antiviral responses in hepatocytes, enabling viral persistence.

The paper determines the crystal structure of the ACDC domain from ApiAP2 proteins in malaria parasites and identifies a potential inhibitor targeting this domain.

The paper uses in silico methods to study the self-assembly of norovirus capsid proteins and revises a previous assembly model.

The paper analyzes amino acid composition and structural patterns in peripheral membrane protein interfaces using experimental and AlphaFold models to identify key residues and functional motifs.

This study identifies two polybasic domains in septin 9 that mediate interaction with phosphoinositides and are critical for septin filament assembly and Golgi integrity.