Francis G. Blankenberg

This study evaluates phage therapy dosing and delivery in a mouse wound infection model, finding topical high-dose repeated administration effective and developing a sustained-release hydrogel system.

This paper develops a single-step chromatography method to purify Pseudomonas aeruginosa phages with high endotoxin reduction and protein impurity removal, suitable for therapeutic use.

This paper develops a physiologically based pharmacokinetic model to characterize the whole-body distribution of bacteriophages in mice, finding rapid elimination and the need for multi-dose regimens.

This study examines how neutrophils affect bacteriophage clearance and pharmacokinetics in mice, finding minimal impact from neutrophils but significant inactivation of phages over time.