Arne Echterhof

This study evaluates phage therapy dosing and delivery in a mouse wound infection model, finding topical high-dose repeated administration effective and developing a sustained-release hydrogel system.

This paper develops a single-step chromatography method to purify Pseudomonas aeruginosa phages with high endotoxin reduction and protein impurity removal, suitable for therapeutic use.

This paper develops a physiologically based pharmacokinetic model to characterize the whole-body distribution of bacteriophages in mice, finding rapid elimination and the need for multi-dose regimens.

This paper develops broad-spectrum bacteriophage therapy cocktails effective against multiple bacterial strains and infections.

This study examines how neutrophils affect bacteriophage clearance and pharmacokinetics in mice, finding minimal impact from neutrophils but significant inactivation of phages over time.