Adam M. Beitz

DIAL is a framework for designing synthetic promoters that generate heritable, tunable gene expression setpoints across cell types.

The paper identifies a quiescent-like state with reduced nuclear size and transcriptional activity that enables efficient TF-mediated conversion of fibroblasts to neurons.

This study identifies proliferation history and transcription factor levels as key drivers of direct conversion of fibroblasts to motor neurons using a synthetic biology approach.

The paper validates genome-wide CRISPR-Cas9 function in Yarrowia lipolytica by quantifying sgRNA efficiency and identifying high-efficiency guides for 94% of genes.