Nathan Wang

STRAIGHT-IN Dual enables efficient, single-copy integration of two DNA payloads into hiPSCs, improving genetic engineering for synthetic biology applications.

This paper introduces DASIT, a protein-based circuit for antigen-specific cell selection, demonstrating its utility in genome engineering, CRISPR screening, and cell therapy manufacturing.

The paper identifies a quiescent-like state with reduced nuclear size and transcriptional activity that enables efficient TF-mediated conversion of fibroblasts to neurons.

This study identifies proliferation history and transcription factor levels as key drivers of direct conversion of fibroblasts to motor neurons using a synthetic biology approach.