Author

Shruti Gupta

Drexel UniversityORCID 0000-0002-6541-5069Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

John R. BetheaiD· 2 shared Kayla L. NguyeniD· 2 shared Aravind MeyyappaniD· 1 shared Erin C. JonesiD· 1 shared Jerome RicardiD· 1 shared Kathryn A. SwansoniD· 1 shared Payam A. FathiiD· 1 shared Roman FischeriD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

John R. BetheaORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintNov 24, 2025

Hippocampal CA3 Nex/Neurod6+ neuron-specific TNFR2 alleviates chronic neuropathic pain by sex-dependently engaging opioid and endocannabinoid pathways

Sreejita Arnab, Payam A. Fathi, Erin C. Jones…·John R. Bethea

This study shows that TNFR2 signaling in hippocampal Nex/Neurod6 neurons is critical for chronic neuropathic pain recovery, acting through sex-dependent opioid and endocannabinoid pathways.

DOI 10.1101/2025.11.24.690195

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintAug 1, 2023

TNFR1/p38αMAPK signaling in Nex+ supraspinal neurons regulates sex-specific chronic neuropathic pain

Kathryn A. Swanson, Kayla L. Nguyen, Shruti Gupta…·John R. Bethea

This study investigates TNFR1/p38αMAPK signaling in Nex+ supraspinal neurons and its role in sex-specific chronic neuropathic pain, finding that it is male-specific and that estrogen receptor β interference affects therapeutic efficacy in females.

3 citations

mouseexperimental assay

𝕏 PostBluesky