Ajay M. Shah

The paper uses genome-scale modelling and stable isotope tracing to study metabolic changes in human cardiac hypertrophy models.

The paper shows NOX4 induces Warburg-type metabolic reprogramming in the healthy adult heart, balancing energy and anabolic demands through transcriptional and epigenetic mechanisms.

This study shows that dietary glutamine reduces H3K27me3 levels in aged mice, improving cardiac function by enhancing autophagy and metabolic health.

This study shows that targeting C42 in PKGI with urolithin A reduces diastolic dysfunction and cardiac remodeling in a mouse model of HFpEF and improves heart tissue function in humans.

This study identifies Aff3ir as a novel gene involved in endothelial cell differentiation by enhancing vascular stem/progenitor cell differentiation in mice.