Author

Saman Sedighi

University of Southern CaliforniaORCID 0000-0002-6568-5974Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Brooke Naomi NakamuraiD· 3 shared Josh NemaniD· 3 shared Diganta DasiD· 2 shared Aaron G. BaughiD· 1 shared Evanthia T. Roussos TorresiD· 1 shared Frances Elaine ChowiD· 1 shared Julie K. Jang· 1 shared Max ReediD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Brooke Naomi NakamuraORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 28, 2026

Chromosome 2q31.2 Deletion Impairs Neuronal Plasticity through Integrated Stress Response Activation

Brooke Naomi Nakamura, Saman Sedighi, Diganta Das…·Josh Neman

This study investigates how a chromosome 2q31.2 deletion affects neuronal plasticity by activating the integrated stress response (ISR) and shows that ISR inhibition improves neuronal function.

DOI 10.64898/2026.04.24.720735

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintNov 25, 2025

AI-Driven and 3D-Bioprinted New Approach Methodology (NAM) Identifies NEO100 as Potent Ultrasound-Activated Therapeutic for Primary and Metastatic Brain Tumors

Rudrajit Majumder, Priyankan Datta, Sreejesh Moolayadukkam…·Josh Neman

DOI 10.1101/2025.11.25.690556

humandeep learning

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Cancer BiologybioRxivPreprintJun 20, 2024

Targeting MDSC-HTR2B to Improve Immune Checkpoint Inhibitors in Breast to Brain Metastasis

Mukund Iyer, Diganta Das, Aaron G. Baugh…·Josh Neman

The paper identifies HTR2B on MDSCs as a target to enhance immune checkpoint inhibitors in breast-to-brain metastasis using clozapine and anti-PD-1 therapy.

DOI 10.1101/2024.06.20.599939

mouseexperimental assay

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