Brian C. H. Cheung

This study uses a computational model to show that fluid-like tumor spheroids cause more ECM remodeling than solid-like spheroids due to shape fluctuations and cellular motility.

This paper introduces a microfluidic rheometer to measure tumor spheroid mechanics and invasiveness in a physiologically relevant setting, finding that tumor stiffness and viscoelastic properties correlate with invasiveness.

This study identifies CD44 as a key mediator of cell traction force generation in hyaluronic acid-rich extracellular matrices, showing its role in modulating collagen network mechanics and tumor invasion.