Cancer BiologybioRxivPreprint
Genomic, Clinical, and Spatial Predictors of Durable Response to BRAF/MEK Inhibition in BRAF-Mutant Melanoma
DOI 10.64898/2026.05.09.721157
Author
Amy Y. Huang
Broad InstituteORCID 0000-0002-6646-6503Unclaimed ORCID profile · follow to get notified of new preprints
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Biology Disciplines
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2024-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 24 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship7 papers
Recent·Most cited
- Cancer BiologyCell Reports MedicinePeer-reviewed
Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment
Yao Yu Yeo, Huaying Qiu, Yunhao Bai…·Sizun Jiang
This study uses spatial multi-omics to compare EBV-positive and EBV-negative cHL, identifying distinct TME features and immunological signatures linked to EBV.
3 citations - ImmunologybioRxivPreprint
Harnessing Inflammatory Monocytes to Overcome Resistance to Anti-PD-1 Immunotherapy
Matthew P. Zimmerman, Amy Y. Huang, Emily K. Cox…·Brian C. Miller
This study shows CD40 agonist therapy reduces tumor growth in antigen presentation-deficient tumors by reprogramming monocytes and requiring IFN-gamma and CD8+ T cells for efficacy.
- Cancer BiologyNature CommunicationsPeer-reviewed
Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma
Jiekun Yang, Cassia Wang, Doris Fu…·Manolis Kellis
The paper identifies a mature dendritic cell subtype associated with improved immune response and prognosis in melanoma patients treated with anti-PD-1 checkpoint inhibitors.
- Cancer BiologybioRxivPreprint
Stratified analysis identifies HIF-2α as a therapeutic target for highly immune-infiltrated melanomas
Amy Y. Huang, Kelly P. Burke, Ryan M. Porter…·David Liu
The paper identifies HIF-2α as a therapeutic target for immune-infiltrated melanomas through stratified analysis of clinical and molecular data.
3 citations - EcologybioRxivPreprint
Effects of Host-Tree Foliage on Polymorphism in an Insect Pathogen
Ari S. Freedman, Amy Y. Huang, Katherine P. Dixon…·Greg Dwyer
The paper measures fitness components of two baculovirus morphotypes and shows how host-tree species influence their coexistence through tradeoffs and environmental heterogeneity.
- BioinformaticsbioRxivPreprint
Cross-domain information fusion for enhanced cell population delineation in single-cell spatial-omics data
Bokai Zhu, Sheng Gao, Shuxiao Chen…·Zongming Ma
This paper introduces CellSNAP, a self-supervised method that integrates spatial, transcriptomic, and proteomic data to improve cell population delineation in spatial-omics datasets.