Delphine De Sutter

This study expands a modular cloning platform to enable rapid, customizable construct assembly for MAPPIT assays, demonstrating its application in studying multiple protein-protein interactions.

The paper uses BioID proximity labeling to show p53 interacts with PML nuclear bodies and SUMOylation proteins in HEK293 cells, linking these interactions to differences in p53 transcriptional activity compared to HCT116 cells.

This study maps the proximity interactome of NR2E3 and its G56R variant using TurboID, revealing interactions with retinal development complexes and identifying BCOR as enriched in the mutant network.

This study identifies SopB-associated host proteins using Virotrap, revealing SopB's interaction with ESCRT-0 and its role in Salmonella's manipulation of host endosomal trafficking.

The paper introduces a T2A split-link system for proximity labeling proteomics to improve control over enzymatic activity and expression levels, enhancing accuracy in identifying protein interactions.