James Craig Forrest

This study uses in vivo single-cell analysis to show that type I IFN signaling and NK cells limit MHV68 infection in lymph nodes, with IFNAR deficiency increasing infected B cell numbers and NK cell depletion enhancing viral spread.

This study shows that KSHV LANA suppresses lytic replication in MHV68, reducing adaptive immune activation, suggesting immune evasion through subthreshold viral replication.

This study shows that p53 activation restricts MHV68-driven GC B cell expansion during latency, with M2 and LMP1 triggering p53-dependent anti-proliferative responses.

This study shows that a replication-dead murine gammaherpesvirus lacking pathogenesis genes can protect against wild-type virus infection by inducing neutralizing antibodies and CD8 T-cell responses.

This paper develops a replication-dead gammaherpesvirus vaccine that protects mice from acute replication, reactivation, and lethal disease caused by wild-type virus.