Darby G. Oldenburg

This study shows that IFNγ and IL-4 regulate lytic infection in myeloid cells via JAK/STAT signaling, with IFNγ restricting lytic replication through multiple mechanisms.

This study shows that KSHV LANA suppresses lytic replication in MHV68, reducing adaptive immune activation, suggesting immune evasion through subthreshold viral replication.

This study shows that p53 activation restricts MHV68-driven GC B cell expansion during latency, with M2 and LMP1 triggering p53-dependent anti-proliferative responses.

This study shows that a replication-dead murine gammaherpesvirus lacking pathogenesis genes can protect against wild-type virus infection by inducing neutralizing antibodies and CD8 T-cell responses.