Irina A. Udalova

The paper identifies CSF1 and TGFβ as key signals for synovial lining macrophage development in mice, which occurs postnatally and is monocyte-independent.

The paper identifies RELM-positive perivascular macrophages that recruit monocytes to the synovium during arthritis onset, contributing to lining macrophage replenishment.

This study identifies Zfp263 as a key transcriptional regulator in neutrophil development, showing it represses ERK1/2 signaling and controls differentiation and effector function acquisition.

The paper identifies deleterious neutrophil states and altered granulopoiesis in sepsis using single-cell multi-omics data from sepsis patients and controls.

This study shows IRF5 promotes pathogenic CD11c+ macrophage differentiation from monocytes in the gut, worsening inflammation during colitis.