Patricia A. DiGiuseppe Champion

This study shows that Mycobacterium marinum switches ESX-1 substrates in response to acidic pH, affecting phagosome lysis and bacterial survival.

This study shows that tyloxapol inhibits ESX-1 secretion in Mycobacterium marinum at low concentrations, affecting its lytic activity and potentially explaining its anti-tuberculosis effects.

This study identifies N-acetyltransferases in M. marinum that link iron uptake, aminoglycoside resistance, and virulence lipid production, revealing their multifunctional roles in pathogenesis.

The paper introduces OnePotNTA, a one-pot method for quantifying N-terminal acetylation in mycobacteria, achieving high coverage and reducing sample preparation time.

This study investigates the relationship between EspE and EspF secretion and their regulatory functions in mycobacteria, finding that their secretion is separable from their gene regulatory roles.

This study shows that loss of PDIM and PGL lipids in M. marinum reduces specific ESX-1 substrate secretion, impacting pathogenesis.

This study identifies EspN as a critical transcription factor regulating the ESX-1 system in M. marinum, which is essential for macrophage infection and disease burden, but its activity is masked by EspM under laboratory conditions.