Author

Sean N. McMillan

University of LeedsORCID 0000-0002-6833-5523Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Charlotte A. ScarffiD· 2 shared Donald A. WinkelmanniD· 2 shared Betty Virok· 1 shared Bipasha BaruaiD· 1 shared Cristina M. RisiiD· 1 shared David Paul KlebliD· 1 shared Eva Forgacs· 1 shared Frank SobottiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Charlotte A. ScarffORCID

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2 papers

Recent·Most cited

BiochemistryNaturePeer-reviewedApr 9, 2025

Swinging lever mechanism of myosin directly demonstrated by time-resolved cryoEM

David Paul Klebl, Sean N. McMillan, Cristina M. Risi…·Howard D. White

This paper uses time-resolved cryoEM to directly observe the swinging lever mechanism of myosin-5, showing its structural changes during ATP hydrolysis and force generation.

41 citationstop 1%

cryo-EMmicroscopy & imaging analysis

𝕏 PostBluesky

BiochemistrybioRxivPreprintFeb 12, 2025

Mavacamten inhibits myosin activity by stabilising the myosin interacting-heads motif and stalling motor force generation

Sean N. McMillan, Jaime R T Pitts, Bipasha Barua…·Charlotte A. Scarff

This paper investigates how mavacamten inhibits myosin activity by stabilizing the interacting-heads motif and affecting cardiac muscle relaxation and contraction.

9 citations

humancryo-EM

𝕏 PostBluesky