Cristina M. Risi

This study reports the high-resolution structure of the native cardiac rigor cross-bridge, revealing how myosin heads and thin filament components coordinate during contraction.

This study uses cryo-EM to reveal how Lmod2 stabilizes actin subunits at the pointed end of filaments and promotes elongation by introducing strain.

This paper uses time-resolved cryoEM to directly observe the swinging lever mechanism of myosin-5, showing its structural changes during ATP hydrolysis and force generation.