Rachael J. M. Bashford-Rogers

This study identifies that organized tertiary lymphoid structures (TLSs) with coordinated B and T cell zoning are associated with durable survival in pancreatic cancer, contrasting with disorganized TLSs in short-term survivors.

This study identifies clonal persistence, tertiary lymphoid structures (TLS) engagement, and coordinated B-T cell immune surveillance as hallmarks of durable tumour control in a long-term survivor of metastatic ccRCC.

This study identifies defective peripheral B cell tolerance in Fibromyalgia Syndrome, revealing immune dysregulation similar to autoimmune diseases.

The paper identifies self-reactive B cells in atherosclerosis-associated tertiary lymphoid organs that produce high-affinity autoantibodies contributing to disease progression.

SpatioEv analyzes spatial data to reveal cell and neighborhood dynamics, identifying disease-specific spatial signatures and developmental trajectories in tissues.

This paper develops bi-specific CAR-iNKT cells targeting CD19 and CD133 for KMT2A-rearranged leukemia, showing superior efficacy over CAR-T in eradicating leptomeningeal disease and inducing remission.

The paper shows that ionizing radiation enhances immunotherapy in pancreatic cancer by increasing tissue-resident NK cells that support CD8 T cell activity through cDC1-dependent mechanisms.

The paper uses long-read sequencing and de novo assembly to identify structural variation in immune system gene regions from a single individual, revealing challenges in current variant calling methods.