John C. Connelly

The paper investigates whether CA repeats are primary targets of MeCP2 and finds no evidence supporting this hypothesis, instead showing they contribute modestly to MeCP2-mediated gene expression.

This study shows that MeCP2's binding to non-CG methylation, specifically mCAC trinucleotides, is critical for normal brain function, as demonstrated by severe Rett syndrome-like phenotypes in mice with a modified MeCP2 domain.

The paper shows MeCP2 binds to mCG and mCAC sequences in mouse brain, with binding density correlating with transcriptional regulation of neuronal genes.